Burkitt’s lymphoma is a malignancy affecting B lymphocytes. The B cells Marketing Research and Data Analysisof patients with Burkitt’s lymphoma grow and divide in an uncontrolled manner. These same cells contain abnormally high levels of the C-MYC protein, a transcription activator that stimulates the expression of a number of genes whose products regulate the cell cycle. Burkitt’s lymphoma cells also contain reciprocal chromosome translocations between chromosome 8 and either chromosome 2, 14, or 22. The translocation breakpoints occur near or within the c-myc gene on chromosome 8 and the immunoglobulin light or heavy chain genes on chromosomes 2 ( light chain), 14 (H chain), or 22 ( light chain). In one patient, the normal and translocated chromosomes resemble the diagram below. Explain why these Burkitt’s lymphoma cells produce high levels of C-MYC protein. Would you expect that these cells would express immunoglobulins? Why do you think that Burkitt’s lymphoma B cells contain these kinds of translocations?
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