Human liver microsomes

175 views 10:37 am 0 Comments June 5, 2023

(c) Compound 2 was incubated with human liver microsomes, resulting in a clearance of 200 mL /min/ million cells. – What does this tell you about its likely human clearance? – From the structure, can you suggest two possible metabolites that might be formed in microsomes? – For each of your suggested routes, provide a mechanism for how the metabolite is formed. – For each of these metabolites, suggest a modification to the original structure that would prevent its formation, given reasons for your choices.GLOBAL ECONOMY ASSIGNMENT TASK

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